RESEARCH
Photo responsive therapeutic nano-medicine
Polymeric hydrogel for therapeutic delievery
Drug combined medical devices
Pharmaceutical engineering
Space medicine
Molecular imaging for cancer surgery
Development of Biomaterial for Clinical Medicine
Bio-adhesive hydrogel for hemostasis
"BioGlue Surgical Adhesive is indicated for use as an adjunct to standard methods of cardiac and vascular repair such as sutures(or staples) to provide hemostasis"
[후보물질의 선정방법]
Safety (toxicity, biodegradable)
Rapid gelation time
Enough physical properties
Easy applying method
[후보물질의 선정]
+
[In vitro evaluation]
[In vivo evaluation]
[지혈을 위한 adhesives 물질 개발 및 평가]
빠른 겔화 속도
조직 접착이 가능
출혈 모델에서의 효과적인 지혈 효과
안전성 평가 필요
Drug Delivery Systems
The preparation of microparticles with radio isotope for embolization therapy
"In radioembolization, implantable radioactive microspheres are delivered into the articles that feed the tumors so that tumor nodules are treated irrespective of their number, size, or locaion"
[Study design]
[Schema of microspheres]
Conjugation of polymer
Preparation of microparticle
Characterization and Stability
Microsphere
polymer
Ester
bond
Amide
bond
DRUG
[Conjugation and Microparticle]
CS-RA-PLGA
(microfluidics) ~ 100um
SMA-PLGA
(homogenizer) ~ 20um
[Future research for microspheres]
Decrease of particle size
Identically spheres
Encapsulation efficiency of drug
Stability of microspheres
miRNA Delivery system for cancer therapy
"New roles for RNA added to our current paradigm for gene and protein regulation Regulomics"
[miRNA : Drug Discovery platform]
Therapeutic Target Gene Search
Screening of miRNA for target gene
Stability and specificity
Internalization & Release
Functional efficacy of Regulomics
[Hydrogel system for miRNA]
[In vitro evaluation]
[In vivo evaluation]
[Challenges of miRNA based therapeutics]
miRNA stability and specificity
Cell internalization
miRNA Release
Cell type specific functional cytoplasmic delivery
The protein delivery system for bone regeneration
"Bone formation is induced through local implantation of microparticle encapsulated bone forming drug"
"Bone formation is induced through local implantation of microparticle encapsulated bone forming drug"
[Delivery of the matrix to the target sites]
[In vitro evaluation]
[In vivo evaluation]
The protein/peptide oral delivery formulation
[ Protein/peptide drug screening ]
GLP-1
Octreotide
각각 현 제약산업 및 난치병 적응증에 해당하는 약물과 흥미를 갖고 있는 약물들을 선별하고 그에 따른 property를 확인하여 Preformulation 통해 예비제형을 디자인
-
가용화제를 이용하여 Solubility&Permeability 개선을 통한 생체이용률 개선
-
CPP(Cell-penetrating peptide)을 이용한 macromolecules 약물의 투과율개선
-
Transporter binding을 이용한 약물전달 효율 개선
-
Nanoparticle을 이용한 Tight junction 투과율 개선
-
Mesoporous silica 및 polymer를 이용한 sustained release 제형 연구
-
위장관(GI tract) 특성을 기반으로 Protein/peptide Oral delivery system 확립
The development of polymer coating method to protect restenosis
"비혈관계 약물 방출 스텐트는 약물의 방출에 의한 질병 치료에 목적을 두고 있으며, 생체적합성 고분자를 이용하여 약물의 방출을 조절하고 부작용을 최소화하며, 약물의 효능을 극대화 시킬 수 있는 membrance 개발"
[Drug Eluting Stent Benefits]
[Gemcitabine]
Reduced clinical restenosis
Comparable safety compared to bare-
metal stent
Improved patient outcomes
Positive trends in various lesion subsets
[In vitro evaluation]
membrane
surface
thickness
기
존
개
발
[Challenge of Drug eluting stent]
Surface adhesion between layer and layer
Controlled drug release
Easy fabrication